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武汉大学学报 英文版 | Wuhan University Journal of Natural Sciences
Wan Fang
Wuhan University
Latest Article
Enantioselective Chlorocyclization of Olefinic Amides with 1,3-Dichloro- 5, 5-Dimethylhydantoin (DCDMH) Catalyzed by (DHQD)2PHAL
ZHOU Qingjun, GUO Chao, LI Xiwang, HE Pei, YANG Guichun, DONG Chune
1. Hubei Collaborative Innovation Center for Advanced Organochemical Materials & Ministry of Education Key Labora-tory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, Hubei, China; 2. School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, China
An efficient catalytic asymmetric chlorocyclization of olefinic amides with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) using hydroquinidine 1,4-phthalazinediyl diether ((DHQD)2PHAL) as organocatalyst has been developed. Series of chiral chloro substituted isobenzofuran-1(3H)-imine derivatives were obtained in good yields (up to 85%) and enantioselectivities (up to 70% ee).
Key words:Asymmetric chlorocyclization; olefinic amides; 1,3-dichloro-5, 5-dimethylhydantoin(DCDMH)
CLC number: TP 305
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