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Histopathology and Ultrastructural Pathology of Cyprinid Herpesvirus II (CyHV-2) Infection in Gibel Carp,Carassius auratus gibelio
JIANG Nan 1,2, XU Jin 1 , MA Jie 1, FAN Yuding 1, ZHOU Yong 1, LIU Wenzhi 1, ZENG Lingbing 1†
1. Division of Fish Disease, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, Hubei, China;2. College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China
Cyprinid herpesvirus II (CyHV-2) infection is identified in cultured gibel carp, Carassius auratus gibelio, with high mortality in China in recent years. Histological pathology includes acute hepatocellular necrosis, splenic necrosis, kidney necrosis, hyperplasia of the secondary lamellae with focal necrosis. Acute necrotic myocarditis and granulocytes are prominent within the cardiac lumen in infected fish. In addition, necrosis is observed in the submucosa and mucosa epithelium of intestinal tract. Edemas are observed in renal glomerulus, submucosa and mucosa epithe-lium of intestinal tract, myocardial cells and neurons. Transmis-sion electron microscopy indicates the cytoplasmic inclusions in splenocytes, glomerulus cells and hematopoietic tissue cells of kidney, epithelial cells of gills and brain cells. The histopathology and ultrastructural pathology in CyHV-2 infected gibel carp are characterized with extensive necrosis and cytoplasmic inclusions in spleen, kidney, gill and brain, which suggests that CyHV-2 may mainly infect the spleen, kidney, gill and brain of fish.
Key words:Cyprinid herpesvirus II; gibel carp; histopathology; ultrastructural pathology; necrosis
CLC number:S941.41+4
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